c-jun Products

Description

The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Bioinformatics

Entrez	16476 Mouse 24516 Rat 3725 Human
Uniprot	AAH68522.1 Human NP_002219 Human P05412 Human
Product By Gene ID	3725
Alternate Names	Activator protein 1 AP1 AP-1 c-Jun enhancer-binding protein AP1 Jun activation domain binding protein jun oncogene jun proto-oncogene Proto-oncogene c-Jun transcription factor AP-1 V-jun avian sarcoma virus 17 oncogene homologp39 v-jun sarcoma virus 17 oncogene homolog (avian) v-jun sarcoma virus 17 oncogene homolog

Research Areas for c-jun

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Hypoxia
Immunology
Innate Immunity
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators
Tumor Suppressors
Wnt Signaling Pathway

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Estrogen Related Receptors Play Roles in Cancer and Neurodegeneration By Eric NeeleyEstrogen receptors come in the form of two distinct forms, ER alpha and ER beta. These nuclear receptors are predominantly activated by the hormone 17-beta-estradiol to control transcription of genes throughout the immune, nervous, car...    Read more.

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