Blk Products

Description

BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

Bioinformatics

Entrez	640 Human
Uniprot	AAH07371 Human BC007371 Human NM_001715.2 Human NP_001706 Human NP_001706.2 Human P51451 Human
Product By Gene ID	640
Alternate Names	B lymphocyte kinase B lymphoid tyrosine kinase BLK nonreceptor tyrosine kinase EC 2.7.10.2 MGC10442 MODY11 p55-Blk tyrosine-protein kinase Blk

Research Areas for Blk

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Protein Kinase