BAZ2A Products

Description

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing

Bioinformatics

Entrez	11176 Human
Uniprot	NP_038477 Human Q9UIF9 Human
Product By Gene ID	11176
Alternate Names	bromodomain adjacent to zinc finger domain protein 2A bromodomain adjacent to zinc finger domain, 2A DKFZp781B109 FLJ45876 hWALp3 KIAA0314FLJ13768 Tip5 TIP5FLJ13780 Transcription termination factor I-interacting protein 5 TTF-I interacting peptide 5 TTF-I-interacting protein 5 WALp3