BAF53A Products

Description

BAF53A encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

Bioinformatics

Entrez	51412 Human 56456 Mouse 86 Human
Uniprot	AAH00949 Human NM_004301 Human NM_177989 Human NP_004292 Human NP_004292.1 Human NP_057272 Human NP_057272 Human NP_817126 Human NP_829888 Human NP004292 Human O96019 Human
Product By Gene ID	86
Alternate Names	actin-like 6A actin-like protein 6A actin-related protein 4,53 kDa BRG1-associated factor A Actin-related protein Baf53a Actl6 Arp4 ArpNbeta arpNbeta BAF complex 53 kDa subunit Baf53a BAF53AACTL6 BAF53MGC5382 BRG1-associated factor 53A hArpN beta INO80 complex subunit K INO80KARPN-BETA

Research Areas for BAF53A

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Extracellular Matrix