Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IP, MA
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, Eq
Applications: WB, Func, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Ca, Eq
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
Aurora-B is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process. Aurora-B is known to be involved in the regulation of centrosome function, bipolar spindle assembly and chromosome segregation. Aurora kinases are localized at the centrosomes of interphase cells, at the poles of the bipolar spindle and in the midbody of the mitotic apparatus. Substrates identified for the Aurora-B kinases include a kinesin-like motor protein, spindle apparatus proteins, histone H3 protein, kinetochore protein and the tumor suppressor protein p53 (1). Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. Identification of Aurora kinases as RasGAP Src homology 3 domain binding protein, also implicates these kinases as potential effectors in the Ras pathway relevant to oncogenesis (2).
Bioinformatics
| Entrez |
Rat
Mouse
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
9212 |
| Alternate Names |
- AIK2EC 2.7.11.1
- AIM1Aik2
- AIM-1STK-1
- ARK2ARK-2
- AurB
- aurkb-sv2
- Aurora- and IPL1-like midbody-associated protein 1
- aurora kinase BSerine/threonine-protein kinase aurora-B
- aurora kinase B-Sv1
- aurora kinase B-Sv2
- Aurora/IPL1-related kinase 2
- aurora-1
- aurora-B
- Aurora-related kinase 2
- EC 2.7.11
- IPL1
- serine/threonine kinase 12
- serine/threonine-protein kinase 12
- STK12aurkb-sv1
- STK5
|
