ATG4B Products

Description

FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. ENZYME REGULATION: Inhibited by N-ethylmaleimide. SUBCELLULAR LOCATION: Cytoplasm (Probable). ALTERNATIVE PRODUCTS: 5 named isoforms produced by alternative splicing.

Bioinformatics

Entrez	23192 Human 66615 Mouse
Uniprot	AAH00719.1 Human NM_178326 Human NP_037457 Human O75385 Human Q9Y4P1 Human
Product By Gene ID	23192
Alternate Names	APG4 autophagy 4 homolog B (S. cerevisiae) APG4 autophagy 4 homolog B Apg4B APG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) AUTL1MGC1353 AUT-like 1 cysteine endopeptidase autophagin-1 Autophagin-1 Autophagy-related cysteine endopeptidase 1 Autophagy-related protein 4 homolog B cysteine protease ATG4B DKFZp586D1822 EC 3.4.22 EC 3.4.22.- hAPG4B KIAA0943

Research Areas for ATG4B

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Phospho-Specific

Related ATG4B Blog Posts

Check out the latest blog posts on ATG4B.

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Animal Models to Study Autophagy By Christina Towers, PhD What is autophagy?Autophagy is the catabolic process that degrades cytoplasmic material via the lysosome. The process of macroautophagy was originally characterized in yeast, where the...    Read more.

ATG4B - a cysteine protease involved in autophagosome elongation Autophagy can be broken down into 4 main stages: phagophore nucleation, autophagosome elongation, autophagosome docking and fusion with a lysosome, and vesicle breakdown and degradation. ATG4B is one of four ATG4 homologs (ATG4A, ATG4B, ATG4C, and ...    Read more.

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