APBA3/Mint-3 Products

Description

The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to munc-18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint 3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer®s Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint 3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer®s disease.

Bioinformatics

Entrez	83611 Rat 9546 Human
Uniprot	NP_004877 Human O96018 Human
Product By Gene ID	9546
Alternate Names	Adapter protein X11gamma amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2) amyloid beta (A4) precursor protein-binding, family A, member 3 MGC:15815 MINT3 mint3 Mint-3 mint-3 Neuronal Munc18-1-interacting protein 3 Neuron-specific X11L2 protein phosphotyrosine-binding/-interacting domain (PTB)-bearing protein X11L2amyloid beta A4 precursor protein-binding family A member 3 X11-like 2 protein

Research Areas for APBA3/Mint-3

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones
Vision