Species: Hu, Mu, Rt, Bv, Pm
Applications: WB, ELISA, ICC/IF, IHC, KO
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Ca
Applications: WB, ELISA, ICC/IF, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
Abhydrolase domain containing 5 (ABHD5) belongs to a very large protein family which contains an alpha/beta hydrolase fold. ABHD5 also contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. Abhd 5 is distinct from other members of this subfamily because the putative catalytic triad contains an asparagine rather than a serine residue.
ABHD5 is a lysophosphatidic acid acyltransferase with a role in phosphatidic acid biosynthesis. ABHD5 may also help regulate cellular storage of triacylglycerol by activating the phospholipase PNPLA2. Additionaly, the ABHD5 protein is thought to play a role in keratinocyte differentiation.
Mutations in this gene are associated with Chanarin-Dorfman syndrome, a triglyceride storage disease characterized by impaired oxidation of long-chain fatty acids. Abhd5 is expressed in many tissues, including brain, liver, skin, skeletal muscle and lymphocytes.
Bioinformatics
| Entrez |
Rat
Human
Mouse
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
51099 |
| Alternate Names |
- abhydrolase domain containing 5
- Abhydrolase domain-containing protein 5,1-acylglycerol-3-phosphate O-acyltransferase ABHD5
- CDS
- CGI58
- EC 2.3.1.51
- IECN2
- Lipid droplet-binding protein CGI-58
- MGC8731
- NCIE2CGI-58
|
