Recent Developments in p53 Antibody Research

P53 is a stress-activated transcription factor, encoded by the TP53 gene. An important tumor suppressor, the protein mediates cellular growth and proliferation, regulating proteins involved in the stress-response. In p53 antibody studies, the protein has been shown to play an important role in the cellular response to DNA damage. Activation of p53 in response to stress stimuli may promote either cell cycle arrest followed by DNA repair, or apoptosis. We at Novus Biologicals are major antibody suppliers of p53 research products.

TP53 is one of the most widely mutated oncogenes, being linked to a large number of carcinomas. It is estimated around 50% of all tumors feature genetically modified or inactivated p53. Not surprisingly, the p53 antibody is widely used in cancer research. Although the function of the protein is to arrest the cell cycle in response to cellular stress, studies have shown that in its mutated form P53 may act as both a tumour suppressor and promoter.

Numerous studies have shown the p53 transcription factor plays transcriptional, posttranscriptional, and posttranslational roles, targeting multiple genes and microRNAs connected to a wide range of cellular activities apart from apoptosis and regulation of cell cycle arrest. In vivo and in vitro studies have shown p53 to be phosphorylated at multiple sites, by a number of different protein kinases, leading to an extensive database of p53 antibody products.

Novus is able to supply conjugated and non-conjugated p53 antibody reagents targeting both the entire protein and specific epitopes, suitable for use in a wide range of normal and cancer cell lines.