CD14 is a well-characterized cell-activating receptor for lipopolysaccharide-binding protein (LBP) and peptidoglycan. It is an important modulator for lipopolysaccharide (LPS)-dependent signaling and is a component of the multi-protein complex containing also containing MD2 and toll-like receptor 4 (TLR4). CD14 is an important component of the innate immune response preferentially expressed on mature cells of monocyte lineage. The CD14 protein contains eleven leucine-rich repeats (LRRs).
