Mitosis, the process of cell division, involves unique interactions between spindle microtubules and chromosomes, which are regulated by protein structures located on chromosomes known as kinetochores. CENPF is a kinetochore-associated protein that is localized to chromatin during the G2 and M phases of mitosis. The main role of CENPF is to secure kinetochore proteins to the correct location surrounding the chromatid and centromere for proper function.
