Transcription factor EB (TFEB) is a member of the MiTF/TFE (Microphthalmia/TFE) subfamily of basic/helix-loop-helix/leucine zipper transcription factors. This group of proteins is involved in the proliferation and development of specific cell types such as osteoclasts or melanocytes. Recently scientists have begun to uncover the roles of MiTF/TFE proteins in organelle biogenesis and energy metabolism (1). TFEB, for example, is a known regulator of lysosome biogenesis.
