GLUT4 is an insulin-sensitive glucose transporter that facilitates insulin-stimulated glucose uptake in adipose tissue, skeletal muscle, and cardiac tissues that specifically express this protein. It is a twelve transmembrane domain multi-pass protein found only in the endosome system and perinuclear cytoplasm. Upon insulin stimulation, GLUT4 translocates to the cell surface. Because of its role in glucose homeostasis, GLUT4 is the key regulator of obesity and obesity-related disease.
