Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular pattern recognition receptor (PRR) that plays an important role in recognizing bacterial pathogens and initiating an immune response. As a PRR, NOD2 recognizes bacterial lipopolysaccharide (LPS), muramyldipeptide (MDP), and other pathogen-associated molecular patterns (PAMPs). NOD2 is a 110 kDa cytoplasmic protein belonging to the Nod-like receptor (NLR) family. Its expression is largely restricted to monocytes and other antigen-presenting cells (APCs).
