TREM1 is pro-inflammatory gene that stimulates neutrophil and monocyte-mediated inflammatory responses. This protein is highly expressed in adult liver, lung and spleen. It is also present in the lymph node, spinal cord and heart tissues. TREM-1 plays a critical role in acute inflammatory responses to bacteria. In organs such as the liver, damage occurring due to irritants such as alcohol causes TREM-1 to amplify the inflammatory response by mediating a signalling pathway.
