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Protein Turnover

Ubiquitin-Mediated Degradation of Cellular Proteins: The Kiss of Death

Ubiquitin is an abundant and essential cellular 9-kd protein that is conserved across evolution from yeast to humans. Ubiquitin is used by cells as a covalent modifier of other proteins both to activate their function and to target them for degradation, depending on the degree of ubiquitination.

Using Ubiquitin Antibodies in Various Disease Research

Ubiquitin is a small, highly conserved protein which plays an important role in protein breakdown, covalently bonding to proteins to mark them for proteolytic degradation in a process called ubiquitination. Ubiquitin also binds to inclusion bodies (accumulations of protein) in pathological conditions such as Parkinson’s and Alzheimer's disease.