Mitofilin was originally described as a heart muscle protein due to its high expression in the heart. Recently, analysis of the human heart mitochondrial proteome demonstrated that Mitofilin is one of the most abundant mitochondrial proteins (1). Researchers have reported finding two alternately spliced Mitofilin variants producing proteins of 88 and 90 kDa, that were detected in immunoblots with Mitofilin antibodies (2).
