Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK1 alpha) is a serine/threonine kinase that forms a complex with IKK beta and NEMO. It plays an essential role in embryonic skin development. Mice with low levels of IKKa show an increase in squamous cell carcinoma and overexpression of IKK-α in the skin of these mice abrogates tumor formation (1).
