Fanconi anemia (FANC) is a heterogenous, autosomal-recessive cancer susceptibility genetic disorder that is characterized by a wide array of symptoms, including congenital defects, progressive bone marrow failure due to DNA-damage hypersensitivity, chromosomal instability, and poor DNA repair. The protein FANCD2 is involved in mediating cellular resistance to DNA cross-linking and DNA synthesis arrest that is triggered by ionizing radiation (IR).
