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Factor X

Factor VIII - a key factor in the clotting process

Hemostasis, or blood clotting, follows tissue injury and involves the deployment of essential plasma procoagulants (such as prothrombin, and Factors X, IX, V, and VIII) that trigger the blood coagulation cascade. This cascade leads to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Defects in Factor VIII and the coagulation cascade result in hemophilia A, a common recessive X-linked coagulation disorder. This disease is characterized by uncontrolled bleeding into joints, muscles, and soft tissues.

CD11b Expression, Leukocyte Adhesion and the Innate Immune System

What is CD11b?

CD11b is an integrin family member which pairs with CD18 to form the CR3 heterodimer. CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on 8% of spleen cells and 44% of bone marrow cells. Functionally, CD11b regulates leukocyte adhesion and migration to mediate the inflammatory response.