estrogen receptor

Keratins, also called cytokeratins, are a family of filamentous structural proteins that form the intermediate filaments within epithelial cells. Keratins are differentially expressed depending on both the epithelial cell origin and degree of differentiation. An antibody to any given keratin is useful either as a stand-alone or part of an antibody panel to help identify or clarify tissue origin. Cytokeratin 18 (CK18) is a 45 kD normal constituent of the hepatocyte cytoskeleton and is expressed in combination with cytokeratin 8.

Steroid receptors (SRs) are a superfamily of ligand-dependent nuclear transcription factors that activate responsive genes response to hormone. Androgen receptors (ARs) are found in a wide variety of tissues, including reproductive organs, central nervous system (CNS), and skeletal muscle. AR signaling is fundamental for the development and function of male reproductive organs, but also plays a role in non-reproductive organs such as muscle, hair follicles, and brain.