TLR1 belongs to the Toll-like receptor (TLR) family, and is a key player in the recognition of pathogens as well as the activation of the innate immunity system. TLRs are highly conserved proteins with a high degree of structural and functional homology from Drosophila to humans. By recognizing pathogen-associated molecular patterns (PAMPs) that are exhibited across a spectrum of ligands, including infectious agents, TLRs modulate cellular cytokine production needed for efficient innate immunity development. Rat reproductive tract studies in Pallodino’s lab with TLR1 antibody demonstrate that the mRNAs of different TLRs and TLR adapter proteins are expressed in contrasting patterns and locations in different rat male reproductive tissues1. The same research group also used the TLR1 antibody to perform analogous detailed studies in epididymal cells and spermatozoa leukocytes2.
Western Blot: TLR1 Antibody
Wong, et al. investigated TLR-mediated signaling in eosinophil activation by microbe-derived molecules through immunoblotting and flow cytometry with a panel of antibodies including the TLR1 antibody3. Their results indicate that microbial infection triggers a plethora of common pathways also linked to allergic inflammation. Further inflammation studies were done with the TLR1 antibody by Abdi et al as they profiled the expression of TLRs in human myeloma cells and the bone marrow environment4. Swedish researchers employed the TLR1 antibody to investigate the expression profiles and regulation of TLR1 and TLR2 in hypoxic-ischemic (HI) neonatal mice brains5. Interestingly, they found that TLR2, but not TLR1, is constitutively expressed in the brain and is directly involved in mediating the HI response.
Novus Biologicals offers TLR1 reagents for your research needs including:
