Identified almost two centuries ago, Parkinson's disease is a neurodegenerative disorder that afflicts an estimated 4-6 million worldwide (www.parkinsons.org). The prevalence of Parkinson's disease is expected to grow considerably as the average age of the population in developed countries increases. Despite the hundreds of millions of dollars devoted annually to Parkinson's research, there is relatively little known about the disease and its treatment. For instance, there is currently no test available to clearly identify the disease, no single environmental or genetic factor proven to cause it, and no known cure for those affected. Therefore, Parkinson's research will continue to be an important and growing research area in the foreseeable future. Novus Biologicals offers a number of excellent immunological tools for Parkinson’s studies, particularly including our LRRK2 antibodies and Parkin antibodies.
Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin, is a leucine-rich repeat kinase family member. LRRK2 is localized in the cytoplasm and is associated with cellular membrane structures and with the mitochondrial outer membrane. Mutations in the LRRK2 gene have been associated with Parkinson's disease, as four LRRK2 gene variants are commonly found in a third of all Parkinson's cases. Novus Biologicals Rabbit Polyclonal LRRK2 antibody (catalog number NB300-268) may be used in Western blot and immunoprecipitation as well as immunofluorescent staining on tissues and cultured cells from human, mouse and bovine. This LRRK2 antibody has been thoroughly tested and has currently been referenced in seven published journal articles.
Parkin (PARK2) is a component of a multiprotein E3 ubiquitin ligase complex which in turn is part of the ubiquitin-proteasome system that catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins for degradation. Mutations in this gene are known to cause a familial form of Parkinson's disease known as autosomal recessive juvenile Parkinson disease. Novus Biologicals rabbit polyclonal Parkin antibody (catalog number R-114-100) may be used in Western blot and immunohistochemical staining of human and rat samples. At this time, the Parkin antibody has been thoroughly characterized and cited in eight published articles.
Novus provides a variety of antibodies for the research of neurodegenerative conditions, including Parkinson's, Alzheimer's disease and more. Please feel free to browse all of our quality guaranteed neuroscience antibodies here.
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