Apolipoprotein E also known as ApoE is a 36kDa protein that is expressed in all lipoprotein fractions in plasma. This protein is produced in high quantities in the liver, brain, spleen, lung and kidney. The function of APOE is to mediate the binding, internalize and catabolize lipoprotein particles. A study carried out by researchers at the Case Western Reserve University in Ohio has recently been highlighted in the BBC Health News. They investigated the effects of ApoE as a step forward in understanding Alzheimer’s disease.
-Western%20Blot-NB110-60531-img0004.jpg "Western Blot: ApoE Antibody")
The main theory behind the cause of this deadly disease is the accumulation of beta-amyloid which causes the formation of amyloid plaques in the brain. ApoE is critical in removing beta-amyloid. ApoE expression is transcriptionally induced through the action of PPAR gamma and Liver X Receptors in coordination with retinoid X Receptors. The scientists at the Case Western Reserve University administered the RXR agonist bexarotene to both young and old mice that had established amyloid plaques. This administration was followed by a rapidly lowered level of beta-amyloid within six hours in young mice and in older mice the level of amyloid plaques were halved within seven days of treatment. These findings could potentially lead to an effective treatment and possible a cure for Alzheimer’s.
Novus Biologicals offers ApoE reagents for your research needs including:
