Androgen R/NR3C4 Products

Description

Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain. The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.

Bioinformatics

Entrez	11835 Mouse 24208 Rat 367 Human
Uniprot	NM_001011645 Human NP_000035 Human P10275 Human
Product By Gene ID	367
Alternate Names	AIS androgen receptor DHTRTFM Dihydrotestosterone receptorHYSP1 HUMARA NR3C4KD Nuclear receptor subfamily 3 group C member 4 SMAX1SBMA spinal and bulbar muscular atrophy

Research Areas for Androgen R/NR3C4

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cellular Markers
Phospho-Specific