AMBRA1 Products

Description

AMBRA1 regulates autophagy and development of the nervous system. It is a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a crucial role in embryogenesis. AMBRA1 is a positive regulator of the Becn1-dependent programme of autophagy, as revealed by its overexpression and by RNA interference experiments invitro. Notably, AMBRA1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death.

Bioinformatics

Entrez	228361 Mouse 55626 Human 59319 Rat
Uniprot	A2AH22 Mouse NP_060219 Human Q9C0C7 Human
Product By Gene ID	55626
Alternate Names	activating molecule in BECN1-regulated autophagy protein 1 autophagy/beclin-1 regulator 1 DCAF3 DDB1 and CUL4 associated factor 3 FLJ20294 KIAA1736activating molecule in beclin-1-regulated autophagy MGC33725 WD repeat domain 94 WDR94

Research Areas for AMBRA1

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Autophagy

Related AMBRA1 Blog Posts

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Animal Models to Study Autophagy By Christina Towers, PhD What is autophagy?Autophagy is the catabolic process that degrades cytoplasmic material via the lysosome. The process of macroautophagy was originally characterized in yeast, where the...    Read more.

Optogenetic Control of Mitophagy: AMBRA1 based mitophagy switch By Christina Towers, PhD Mitophagy in the BrainSelective autophagic degradation of damaged mitochondria, known as mitophagy, has been described as a cyto-protective process. Accordingly, defects in mitophagy h...    Read more.

Beclin 2, a mammal-specific homolog of Beclin 1 with unique functional similarities and differences Beclin 2 (BECN2) is also called Beclin-1-like protein 1/ BECN1P1 and it was recently identified by He et al 2013 as a mammal-specific homolog of the evolutionarily conserved protein Beclin 1 which is well established for its role in the regulation ...    Read more.

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