Species: Hu, Mu, Rt, Ha
Applications: WB, IP, ChIP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, NULL
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Ku80, also known as XRCC5, plays a role in many diverse processes including cell signaling, proliferation, DNA repair, replication, transcriptional activation and apoptosis.
As one half of the heterodimer complex Ku, Ku80 is required for proper maintenance of the telomeric C strand. Ku80 also plays a role in DNA repair as an essential subunit of DNA-dependent protein kinase (DNA-PK) that phosphorylates certain transcription factors (Sp1, Oct-1 and p53). The heterodimer Ku binds double stranded DNA breaks for non-homologous end joining repair. Ku mutants are defective in T-DNA integration and over-expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
7520 |
| Alternate Names |
- 80kDa
- ATP-dependent DNA helicase 2 subunit 2
- ATP-dependent DNA helicase II 80 kDa subunit
- CTC85
- CTCBF
- EC 3.6.4.-
- FLJ39089
- G22P2
- KARP1
- KARP-1
- KU80
- Ku80
- Ku86 autoantigen related protein 1,86 kDa subunit of Ku antigen
- Ku86DNA repair protein XRCC5
- KUB2
- NFIV
- Thyroid-lupus autoantigen
- TLAA
- X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining)CTC box-binding factor 85 kDa subunit
- X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining; Ku autoantigen, 80kD)
- X-ray repair cross-complementing protein 5
- X-ray repair, complementing defective, repair in Chinese hamster
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