PDX-1/IPF1 Antibody - BSA Free

PDX1, also known as IDX-1, IPF-1, STF-1, and MODY4 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. During development, PDX1 specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, it is required for maintaining the hormone-producing phenotype of the beta-cell. PDX1 is located in both the nucleus and cytosol on a cellular level, while in tissue it is distinct to the duodenum and pancreas. Defects in PDX1 gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). Recently, research of PDX1 ranges from an important role in the malaria parasite (PMID: 23039077) to mutations in PDX1 leading to neonatal diabetes (PMID: 20009086).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Canine.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-22150	Applications	Species
Aguiar BA, Orechio D, Fratini P et al. Isolation and Characterization of Pancreatic Canine Fetal Cells at the Final Stage of Gestation. Anat Rec (Hoboken). 2018-10-17 [PMID: 30332726] (Canine)		Canine
Ramdas M, Sharma S, Kaul D, Bhatia A. Possible role of miR-2909 RNomics in arsenic mediated pancreatic B-cell dysfunction. Journal of Trace Elements in Medicine and Biology 2018-12-01 [PMID: 30262289] (WB, Mouse)	WB	Mouse

Array NBP2-22150

• PDX-1/IPF1 Antibodies
• PDX-1/IPF1 Lysate
• PDX-1/IPF1 Proteins