TCF-2/HNF-1 beta Antibody

TCF2 encodes transcription factor 2, a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Chemotaxis, ICC/IF, IF/IHC.

Showing Publications 1 - 7 of 7.

Publications using NBP1-89680	Applications	Species
Holokai L, Chakrabarti J, Lundy J et al. Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma Cancers 2020-12-17 [PMID: 33348809] (ICC/IF, Human)	ICC/IF	Human
Goyeneche AA, Koch M, Bell MC, Telleria CM. Long-term primary culture of a clear cell ovarian carcinoma reveals an epithelial-mesenchymal cooperative interaction. Cancer Cell Int 2015-01-01 [PMID: 26405433] (IF/IHC, Human)	IF/IHC	Human
Davidson B. Hepatocyte nuclear factor-1-beta is not a specific marker of clear cell carcinoma in serous effusions. Cancer Cytopathol 2014-02-01 [PMID: 24115587] (IF/IHC)	IF/IHC
Donthamsetty S, Bhave VS, Mars WM et al. Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis. PLoS One 2013-01-01 [PMID: 24058607]
Szponar A, Yusenko MV, Kuiper R et al. Genomic profiling of papillary renal cell tumours identifies small regions of DNA alterations: a possible role of HNF1B in tumour development. Histopathology 2011-05-01 [PMID: 21438902]
Raven AP. Impairing hepatocyte regeneration to determine the regenerative capacity of the biliary epithelium Thesis 2018-01-01 (IF/IHC)	IF/IHC
Zhang FF, Liu YH, Wang DW et al. Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation Diabetologia 2020-02-01 [PMID: 32008054] (Chemotaxis, Mouse)	Chemotaxis	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-P	Human	09/25/2014	View Summary Application Immunohistochemistry-Paraffin Sample Tested Human fetal pancreas Species Human Lot J89927

Array NBP1-89680

• TCF-2/HNF-1 beta Antibodies
• TCF-2/HNF-1 beta ELISA Kits
• TCF-2/HNF-1 beta Lysate
• TCF-2/HNF-1 beta Proteins