PDX-1/IPF1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PDX-1 (Pancreas-duodenum homeobox 1; also IPF-1, IDX-1, STF-1, GSF and IUF-1) is a 42 kDa member of the IPF-1 subfamily, ANTP homeobox family of proteins. It is expressed in developing pancreas, plus pancreatic beta -cells, and duodenal crypt epithelium. In concert with HNF6, PDX-1 drives pancreatic endocrine cell formation by regulating the expression of neurogenin-3. In adult beta -cells, PDX-1 binds to PCIF-1 to regulate insulin production. Mouse PDX-1 is 284 amino acids (aa) in length (Accession # P52946). It contains one transactivation domain (aa 13‑73) a PBX1 P-P-M-W-K dimerization motif (aa 119‑124), and a DNA-binding homeodomain with an embedded NLS (aa 148‑206). Full-length mouse PDX-1 shares 94% and 88% aa identity with rat and human PDX-1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: ICC, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using AF2517	Applications	Species
J Dereke, E Ekblad, B Weström, C Erlanson-A, M Landin-Ols, I Sjöholm, M Hillman Structural and immunoendocrine remodeling in gut, pancreas and thymus in weaning rats fed powdered milk diets rich in Maillard reactants Scientific Reports, 2022-03-08;12(1):4039. 2022-03-08 [PMID: 35260716] (ICC, Rat)	ICC	Rat
Chinmai Patibandla, Zahidul Islam Khan, Louise MacGregor, Mark James Campbell, Steven Patterson Costus pictus D. Don leaf extract stimulates GLP-1 secretion from GLUTag L-cells and has cytoprotective effects in BRIN-BD11 beta -cells Journal of Ethnopharmacology 2020-10-05 [PMID: 32422353]
C Miyagi-Shi, Y Nakashima, N Kobayashi, I Saitoh, M Watanabe, H Noguchi Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA Sci Rep, 2018-08-17;8(1):12341. 2018-08-17 [PMID: 30120295] (ICC, Mouse)	ICC	Mouse
HM La, JA Mäkelä, AL Chan, FJ Rossello, CM Nefzger, JMD Legrand, M De Seram, JM Polo, RM Hobbs Identification of dynamic undifferentiated cell states within the male germline Nat Commun, 2018-07-19;9(1):2819. 7/19/2018 [PMID: 30026551]
Haruo Hashimoto, Tsutomu Kamisako, Takahiro Kagawa, Seiki Haraguchi, Mika Yagoto, Ri-ichi Takahashi et al. Expression of pancreatic and duodenal homeobox1 (PDX1) protein in the interior and exterior regions of the intestine, revealed by development and analysis of Pdx1 knockout mice Laboratory Animal Research 2015-06-26 [PMID: 26155204]
Semache M, Zarrouki B, Fontes G, Fogarty S, Kikani C, Chawki M, Rutter J, Poitout V Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3beta in pancreatic beta-cells. J Biol Chem, 2013-07-12;288(34):24825-33. 2013-07-12 [PMID: 23853095] (Western Blot, Mouse)	Western Blot	Mouse
Sneddon , Julie B, Borowiak , Malgorza, Melton , Douglas Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 2012-10-07;491(7426):765-8. 2012-10-07 [PMID: 23041930] (ICC, Mouse)	ICC	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Jonatan Dereke	IHC-P	Rat	04/29/2020	View Summary Application Immunohistochemistry-Paraffin Sample Tested Pancreas tissue Species Rat Lot KZM0115111 Comments Comments We used this antibody at a 1:400 dilution for our assays.

Array AF2517

• PDX-1/IPF1 Antibodies
• PDX-1/IPF1 Lysate
• PDX-1/IPF1 Proteins