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CD98 antibody

xCT: Friend or Foe?

There are two opposing sides to the controversial cysteine/glutamate antiporter. On one hand, it can be viewed a guardian of the cell, protecting it from the damaging oxidative stress that can cause cell death and even cancer. But, conversely, it has a dark side, actually facilitating cancer in a number of ways.

Glutathione and xCT: Chemoresistance in Tumor Cells

Glutathione, called GSH in its reduced form and GSSG or L(-)-Glutathione in its oxidized form, is an endogenous antioxidant found in most cells in the body.