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Oval Cell Marker Antibody (OC2-1C6) [FITC]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC
Clone
OC2-1C6
Clonality
Monoclonal
Host
Rat
Conjugate
FITC

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Oval Cell Marker Antibody (OC2-1C6) [FITC] Summary

Description
This product is provided as conjugated tissue culture supernatant. Due to the crude preparation of the antibody material, excess dye may remain in the final product. We highly recommend taking necessary precautions, such as adding additional wash steps and running proper controls.
Immunogen
Nonparenchymal cells from DDC-treated mice to induce the oval cell response.
Localization
Cell surface
Marker
Hepatic periductal cell Marker
Specificity
Specific for proliferating hepatic periductal cells.
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Tissue culture supernatant

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Background

Liver is well known to possess facultative stem cells which can be activated in response to injury and hepatic stem cell activation was first described in rat model, wherein, chemical damage in combination with partial hepatectomy resulted in the emergence of a new cell type which was described according to its nuclear morphology as "oval cells". The word 'oval cells' is now employed to define population of small proliferating cells with oval-shaped nuclei which arise within liver tissue following certain types of hepatic injury. Oval cell proliferation is activated when the proliferative capacity of hepatocytes is impaired, as well as in certain models of carcinogenesis. Histologically, hepatic tissue is highly complex and contains many different cell types including various kinds of hepatocytes, ducts, hematopoietic cells, endothelial cells, macrophages, stellate cells etc., and the oval cells have been proposed to be bipotential progenitor cells capable of generating both hepatocytes and bile ducts. Due to their bipotency and high clonogenicity, oval cells have been considered putative liver stem cells and research is in progress for elucidation of signaling molecules involved in controlling the activation, proliferation and differentiation of this unique cell population. Our oval cell antibodies have been developed against hepatic nonparenchymal cells (NPCs) from mice undergoing oval cell activation and with these antibodies, it is now possible to perform microarray analysis of distinct liver cell populations during induced oval cell response or certain pathological conditions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Oval Cell Marker Antibody (NBP1-18965F) (0)

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Secondary Antibodies

 

Isotype Controls

Additional Oval Cell Marker Products

Array NBP1-18965F

Research Areas for Oval Cell Marker Antibody (NBP1-18965F)

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