Mouse IL-27 p28/IL-30 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-27 is a heterodimeric cytokine that is composed of EBI3 (which is related to the p40 subunit of IL-12 and IL-23) and p28 (which is related to the p35 chain of IL-12). IL-27 is expressed by monocytes, endothelial cells, and dendritic cells, and it signals through a receptor complex composed of IL-27 R alpha/WSX-1/TCCR and gp130. IL-27 induces IL-12 receptor expression on naïve CD4+ T cells, sensitizing them to subsequent IL-12 induced Th1 development. It also functions as an anti-inflammatory cytokine by limiting T and NKT cell activity.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using M2728	Applications	Species
Zhou, B;Elean, M;Arce, L;Fukuyama, K;Tomotsune, K;Dentice Maidana, S;Saha, S;Namai, F;Nishiyama, K;Vizoso-Pinto, MG;Villena, J;Kitazawa, H; The Mucus-Binding Factor Mediates Lacticaseibacillus rhamnosus CRL1505 Adhesion but Not Immunomodulation in the Respiratory Tract Microorganisms 2024-06-16 [PMID: 38930591] (Mouse)		Mouse
Elean, M;Raya Tonetti, F;Fukuyama, K;Arellano-Arriagada, L;Namai, F;Suda, Y;Gobbato, N;Nishiyama, K;Villena, J;Kitazawa, H; Immunobiotic Ligilactobacillus salivarius FFIG58 Confers Long-Term Protection against Streptococcus pneumoniae International journal of molecular sciences 2023-10-30 [PMID: 37958756] (Mouse)		Mouse
M Tomokiyo, FR Tonetti, H Yamamuro, R Shibata, K Fukuyama, N Gobbato, L Albarracin, MSR Rajoka, AKMH Kober, W Ikeda-Ohts, J Villena, H Kitazawa Modulation of Alveolar Macrophages by Postimmunobiotics: Impact on TLR3-Mediated Antiviral Respiratory Immunity Cells, 2022-09-25;11(19):. 2022-09-25 [PMID: 36230948] (Mouse)		Mouse
B Min, D Kim, MJ Feige IL-30� (IL-27A): a familiar stranger in immunity, inflammation, and cancer Experimental & Molecular Medicine, 2021-05-28;53(5):823-834. 2021-05-28 [PMID: 34045653] (Mouse)		Mouse
Sha X, Meng S, Li X, Xi H, Maddaloni M, Pascual D, Shan H, Jiang X, Wang H, Yang X Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway. J Biol Chem, 2015-06-17;290(31):19307-18. 2015-06-17 [PMID: 26085094] (Mouse)		Mouse
de Almeida Nagata D, Demoor T, Ptaschinski C, Ting H, Jang S, Reed M, Mukherjee S, Lukacs N IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis. Am J Pathol, 2014-04-13;184(6):1807-18. 2014-04-13 [PMID: 24726498] (Mouse)		Mouse
Owens BM, Beattie L, Moore JW, Brown N, Mann JL, Dalton JE, Maroof A, Kaye PM IL-10-Producing Th1 Cells and Disease Progression Are Regulated by Distinct CD11c+ Cell Populations during Visceral Leishmaniasis. PLoS Pathog., 2012-07-26;8(7):e1002827. 2012-07-26 [PMID: 22911108] (Mouse)		Mouse
Stumhofer JS, Tait ED, Quinn WJ, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grotzinger J, Cancro MP, Levin SD, Hunter CA A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat. Immunol., 2010-11-07;11(12):1119-26. 2010-11-07 [PMID: 21057510] (Mouse)		Mouse
Molle C, Goldman M, Goriely S Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process. J. Immunol., 2010-01-18;184(4):1784-92. 2010-01-18 [PMID: 20083668] (Mouse)		Mouse
Vultaggio A, Nencini F, Fitch PM, Fili L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG, Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SE, Parronchi P Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7. J. Immunol., 2009-01-15;182(2):880-9. 2009-01-15 [PMID: 19124731] (Mouse)		Mouse
Shinohara ML, Kim JH, Garcia VA, Cantor H Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity, 2008-07-18;29(1):68-78. 2008-07-18 [PMID: 18619869] (Mouse)		Mouse
Guo B, Chang EY, Cheng G The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 2008-05-01;118(5):1680-90. 2008-05-01 [PMID: 18382764] (Mouse)		Mouse
Xu J, Racke MK, Drew PD Peroxisome proliferator-activated receptor-alpha agonist fenofibrate regulates IL-12 family cytokine expression in the CNS: relevance to multiple sclerosis. J. Neurochem., 2007-12-01;103(5):1801-10. 2007-12-01 [PMID: 17727629] (Mouse)		Mouse
Fitzgerald DC, Ciric B, Touil T, Harle H, Grammatikopolou J, Das Sarma J, Gran B, Zhang GX, Rostami A Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol., 2007-09-01;179(5):3268-75. 2007-09-01 [PMID: 17709543] (Mouse)		Mouse
Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, Ganea D The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis. J. Immunol., 2007-06-15;178(12):8138-47. 2007-06-15 [PMID: 17548652] (Mouse)		Mouse
Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, De Wit D, Willems F, Goldman M, Goriely S IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3. J. Immunol., 2007-06-15;178(12):7607-15. 2007-06-15 [PMID: 17548596] (Mouse)		Mouse
Liu J, Guan X, Ma X Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways. J. Exp. Med., 2007-01-16;204(1):141-52. 2007-01-16 [PMID: 17227910] (Mouse)		Mouse
Show All 17 Publications. Collapse Publications.

Array M2728

• IL-27 p28/IL-30 Antibodies
• IL-27 p28/IL-30 Proteins and Enzymes
• IL-27 p28/IL-30 ELISAs