Goat anti-Mouse Lambda Light Chain Secondary Antibody [HRP]

All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L; Lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins). This antibody stains only lambda light chain containing cells in human lymphoid tissues.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Secondary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ELISA, IF/IHC.

Showing Publications 1 - 4 of 4.

Publications using NB7552	Applications	Species
Hung L The Monoclonal Antibody Recognized Apoptosis-Associated Protein in PCV2-Infected Peripheral Blood Mononuclear Cells Preprints 2019-11-13 (ELISA, Mouse)	ELISA	Mouse
Dong Y, Pi X, Bartels-Burgahn F et al. Structural principles of B cell antigen receptor assembly Nature 2022-12-01 [PMID: 36228656]
Lim B, Kydd L, Jaworski J Engineering a reporter cell line to mimic the high oligomannose presenting surface immunoglobulin of follicular lymphoma B cells Sci Rep 2021-01-09 [PMID: 33420165] (IF/IHC, Mouse) Details: Citation using the HRP version of this antibody.	IF/IHC	Mouse
Bauer E, Schlederer M, Scheicher R et al. Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice. Oncotarget. [PMID: 26919255] Details: Citation using the HRP form of this antibody.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Ming Lu	WB	Mouse	09/03/2014	View Summary Application Western Blot Sample Tested Human pancreatic cancer cell lysates and tumor grow in mouse of same cells Species Mouse Lot A14

Array NB7552

• Lambda Light Chain Antibodies
• Lambda Light Chain ELISA Kit
• Lambda Light Chain Antibodies