Mouse IgG2a Isotype Control (133304) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IgG is the most abundant of the five classes of mammalian immunoglobulins in serum. IgG molecules (~150 kDa) consist of two ~50 kDa heavy chains and two 25 kDa light chains connected by disulfide bonds. Antibody specificity is conferred by a combination of somatic rearrangement and hypermutation within variable regions. Mouse IgG isotypes IgG1, IgG2a and IgG2b share approximately 64-78% amino acid sequence identity within the heavy chain constant region domains (CH1, CH2 and CH3) and may vary in their interaction with complement, NK and mast cells, induction or inhibition by specific cytokines, and ability to cross the placenta.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Isotype Controls are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Hamster, Primate - Chlorocebus aethiops (African Green Monkey).

We have publications tested in 7 applications: ChIP Control, Control, Flow Cytometry, Functional Assay, ICC, IHC, Isotype Control.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using MAB0031	Applications	Species
Luis M. Cardoso dos Santos, Yannick Avila, Domitille Schvartz, Anne-Laure Rougemont, Marie-Luce Bochaton-Piallat, Isabelle Ruchonnet-Metrailler Laser microdissection, proteomics, and multiplex immunohistochemistry: a bumpy ride into the study of paraffin-embedded fetal and pediatric lung tissues Frontiers in Medicine 2023-08-29 [PMID: 37706027]
Amina Mohammadalipour, Christian A. Showalter, Harrison T. Muturi, Amir M. Farnoud, Sonia M. Najjar, Monica M. Burdick Cholesterol depletion decreases adhesion of non-small cell lung cancer (NSCLC) cells to E-selectin American Journal of Physiology-Cell Physiology 2023-08-01 [PMID: 37399498]
T Dahlet, M Truss, U Frede, H Al Adhami, AF Bardet, M Dumas, J Vallet, J Chicher, P Hammann, S Kottnik, P Hansen, U Luz, G Alvarez, G Auclair, J Hecht, PN Robinson, C Hagemeier, M Weber E2F6 initiates stable epigenetic silencing of germline genes during embryonic development Nature Communications, 2021-06-11;12(1):3582. 2021-06-11 [PMID: 34117224] (ChIP Control, Mouse)	ChIP Control	Mouse
Mondal SK, Whiteside TL. Immunoaffinity-Based Isolation of Melanoma Cell-Derived and T Cell-Derived Exosomes from Plasma of Melanoma Patients Methods in Molecular Biology 2022-05-05 [PMID: 33704724]
CK Vadivel, M Gluud, S Torres-Rus, L Boding, A Willerslev, TB Buus, TK Nielsen, JL Persson, CM Bonefeld, C Geisler, T Krejsgaard, AT Fuglsang, N Odum, A Woetmann JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL) Cancers, 2021-01-14;13(2):. 2021-01-14 [PMID: 33466582] (ICC, Human)	ICC	Human
Xidan Zhu, Jia Feng, Wenguang Fu, Xiaojia Shu, Xue Wan, Jinbo Liu Effects of cisplatin on the proliferation, invasion and apoptosis of breast cancer cells following beta ‑catenin silencing International Journal of Molecular Medicine 2020-03-16 [PMID: 32186756]
Sara Abouelasrar Salama, Mieke Gouwy, Alexandra De Zutter, Noëmie Pörtner, Lotte Vanbrabant, Nele Berghmans et al. Induction of Chemokines by Hepatitis C Virus Proteins: Synergy of the Core Protein with Interleukin-1 beta and Interferon-gamma in Liver Bystander Cells Journal of Interferon & Cytokine Research 2020-04-01 [PMID: 32031878]
R Xu, L Chen, WT Yang Aberrantly elevated Bmi1 promotes cervical cancer tumorigenicity and tumor sphere formation via enhanced transcriptional regulation of Sox2 genes Oncol. Rep., 2019-06-06;0(0):. 2019-06-06 [PMID: 31173263] (IHC, Human)	IHC	Human
Ghislain Auclair, Julie Borgel, Lionel A. Sanz, Judith Vallet, Sylvain Guibert, Michael Dumas et al. EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos Genome Research 2016-02-01 [PMID: 26576615]
Bufe B, Schumann T, Kappl R, Bogeski I, Kummerow C, Podgorska M, Smola S, Hoth M, Zufall F Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens. J Biol Chem, 2015-01-20;290(12):7369-87. 2015-01-20 [PMID: 25605714] (ICC, Human)	ICC	Human
Zhang X, Sheng J, Austin S, Hoornweg T, Smit J, Kuhn R, Diamond M, Rossmann M Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers. J Virol, 2014-10-29;89(1):743-50. 2014-10-29 [PMID: 25355881] (Isotype Control, Hamster)	Isotype Control	Hamster
Berglin L, Bergquist A, Johansson H, Glaumann H, Jorns C, Lunemann S, Wedemeyer H, Ellis E, Bjorkstrom N In situ characterization of intrahepatic non-parenchymal cells in PSC reveals phenotypic patterns associated with disease severity. PLoS ONE, 2014-08-20;9(8):e105375. 2014-08-20 [PMID: 25141347] (Isotype Control, Human)	Isotype Control	Human
Jennifer Gordon, Ilker K. Sariyer, Marisol De La Fuente-Granada, Brian J. Augelli, Jessica Otte, S. Ausim Azizi et al. Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen PLoS ONE 2013-06-21 [PMID: 23805194]
Pal , Pankaj, Dowd , Kimberly, Brien , James D, Edeling , Melissa, Gorlatov , Sergey, Johnson , Syd, Lee , Iris, Akahata , Wataru, Nabel , Gary J, Richter , Mareike, Smit , Jolanda, Fremont , Daved H, Pierson , Theodore, Heise , Mark T, Diamond , Michael Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus. PLoS Pathog, 2013-04-18;9(4):e1003312. 2013-04-18 [PMID: 23637602] (Functional Assay, Primate - Chlorocebus aethiops (African Green Monkey))	Functional Assay	Primate - Chlorocebus aethiops (African Green Monkey)
Murphy , Sean V, Lim , Rebecca, Heraud , Philip, Cholewa , Marian, Le Gros , Mark, de Jonge , Martin D, Howard , Daryl L, Paterson , David, McDonald , Courtney, Atala , Anthony, Jenkin , Graham, Wallace , Euan M Human amnion epithelial cells induced to express functional cystic fibrosis transmembrane conductance regulator. PLoS ONE, 2012-09-28;7(9):e46533. 9/28/2012 [PMID: 23029546]
Berahovich RD, Zabel BA, Penfold ME, Lewen S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ CXCR7 protein is not expressed on human or mouse leukocytes. J. Immunol., 2010-10-01;185(9):5130-9. 2010-10-01 [PMID: 20889540] (Flow Cytometry, Human)	Flow Cytometry	Human
Roulet V, Satie AP, Ruffault A, Le Tortorec A, Denis H, Guist'hau O, Patard JJ, Rioux-Leclerq N, Gicquel J, Jegou B, Dejucq-Rainsford N Susceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro. Am. J. Pathol., 2006-12-01;169(6):2094-103. 2006-12-01 [PMID: 17148672] (Control, Human)	Control	Human
Ebert EC, Mehta V Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell. Immunol., 2006-08-17;241(1):7-13. 2006-08-17 [PMID: 16914126] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 18 Publications. Collapse Publications.

Array MAB0031

• IgG2a Antibodies
• IgG2a ELISA Kits
• IgG2a Isotype Controls
• IgG2a Antibodies
• IgG2a Proteins and Enzyme