Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human R-Spondin 3 DuoSet ELISA, 15 Plate
Cristin 1
CRISTIN1
FLJ14440
hPWTSR
hRspo3
Protein with TSP type-1 repeat
PWTSR
Roof plate-specific spondin-3
RSPO3
R-spondin 3 homolog (Xenopus laevis)
RSpondin 3
R-Spondin 3
R-spondin-3
Thrombospondin type-1 domain-containing protein 2
thrombospondin, type I, domain containing 2
THSD2
Background
R-Spondin 3 (RSPO3; Cristin 1) is a secreted Wnt regulating protein that is critical for development of the placental labyrinthine layer. It is expressed in the roof plate, tail, somites, otic vesicles, cephalic mesoderm, truncus arteriosus, atrioventricular canal of the developing heart, and strongly but transiently in developing limbs. R-Spondins regulate Wnt/ beta -catenin by competing with the Wnt antagonist DKK-1 for binding to the Wnt co-receptors LRP-6 and Kremen, reducing their DKK-1-mediated internalization. Reports differ on whether R-Spondins bind LRP-6 directly.
Publications for R-Spondin 3 (DY3500)(1)
We have publications tested in 1 confirmed species: Human.
