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Recombinant Mouse ErbB2/Her2 His (C-Term) Protein

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SDS-Page: Recombinant Mouse ErbB2/Her2 His (C-Term) Protein [NBP3-18206] - Recombinant Mouse ErbB2/Her2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 100-110 kDa.
SDS-Page: Recombinant Mouse ErbB2/Her2 His (C-Term) Protein [NBP3-18206] - Recombinant Mouse ErbB2/Her2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 100-110 kDa.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications PAGE
Concentration
LYOPH

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Recombinant Mouse ErbB2/Her2 His (C-Term) Protein Summary

Description
A recombinant protein with a C-terminal 6xHis tag corresponding to the amino acids Thr23-Thr653 of Mouse ErbB2/Her2.

Source: HEK293

(Accession #: NP_001003817.1)

Store at -20C to -80C long term. After reconstitution, the product is stable at -20C for 3 months, and 2-8C for up to 1 week.
Source
HEK293
Protein/Peptide Type
Recombinant Protein
Gene
ERBB2
Purity
>97%, by SDS-PAGE
Endotoxin Note
< 0.1 EU/ug of the protein by LAL method

Applications/Dilutions

Dilutions
  • SDS-Page

Packaging, Storage & Formulations

Storage
Store at -20C.
Buffer
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4
Concentration
LYOPH
Purity
>97%, by SDS-PAGE
Reconstitution Instructions
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water

Alternate Names for Recombinant Mouse ErbB2/Her2 His (C-Term) Protein

  • CD340 antigen
  • CD340
  • c-erb B2/neu protein
  • EC 2.7.10
  • EGFR2
  • ErbB2
  • HER2
  • HER-2
  • HER2EC 2.7.10.1
  • herstatin
  • Metastatic lymph node gene 19 protein
  • MLN 19
  • MLN19
  • Neu Oncogene
  • NEUHER-2/neu
  • neuroblastoma/glioblastoma derived oncogene homolog
  • NGL
  • NGLTKR1
  • p185erbB2
  • Proto-oncogene c-ErbB-2
  • Proto-oncogene Neu
  • receptor tyrosine-protein kinase erbB-2
  • TKR1
  • Tyrosine kinase-type cell surface receptor HER2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)

Background

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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FAQs for ErbB2/Her2 Recombinant Protein (NBP3-18206). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in getting antibodies for HER that would work in flow cytometry. Could you recommend some choices?
    • A list of our ErbB2 antibodies validated for use in flow cytometry can be found here /productsearch/HER2#fq=common_name%3A%22ErbB2%2FHER2%22&fq=category%3A%22Primary%20Antibodies%22&fq=applications%3A%22Flow%20Cytometry%22

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Bioinformatics

Gene Symbol ERBB2