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ErbB2/Her2 Antibody (191924) [DyLight 488]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, CyTOF-ready, ELISA, ELISA(Cap), ELISA(Det), ICC/IF
Clone
191924
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB1129U-100UG
Alexa Fluor 405
FAB1129V-100UG
Alexa Fluor 488
FAB1129G-025
Alexa Fluor 532
FAB1129X
Alexa Fluor 594
FAB1129T-025
Alexa Fluor 647
FAB1129R-025
Alexa Fluor 700
FAB1129N-100UG
Alexa Fluor 750
FAB1129S-100UG
Allophycocyanin
FAB1129A
Allophycocyanin/Cy7
FAB1129APCCY7
Biotin
FAB1129B
DyLight 350
FAB1129D
DyLight 405
FAB1129E
DyLight 550
FAB1129L
DyLight 594
FAB1129M
DyLight 650
FAB1129W
DyLight 680
FAB1129Y
DyLight 755
FAB1129Z
FITC
FAB1129F
HRP
FAB1129H
Janelia Fluor 549
FAB1129I
Janelia Fluor 646
FAB1129J
PE/Atto594
FAB1129PEATT594
PE/Cy5.5
FAB1129PECY55
PE/Cy7
FAB1129PECY7
PerCP
FAB1129C
Phycoerythrin
FAB1129P
Unconjugated
MAB1129-100
mFluor Violet 450 SE
FAB1129MFV450
mFluor Violet 500 SE
FAB1129MFV500
mFluor Violet 610 SE
FAB1129MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB1129-100
Carrier Free
FAB1129A
Carrier Free
FAB1129P
Carrier Free
MAB1129-SP
Carrier Free
MAB1129-100
Carrier Free
MAB1129-500
Carrier Free
FAB1129R-025
Carrier Free
FAB1129G-025
Carrier Free
FAB1129T-025
Carrier Free
FAB1129V-100UG
Carrier Free
FAB1129U-100UG
Carrier Free
FAB1129S-100UG
Carrier Free
FAB1129N-100UG
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ErbB2/Her2 Antibody (191924) [DyLight 488] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human ErbB2/Her2
Thr23-Thr652
Accession # P04626
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
ERBB2
Purity
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
  • Flow Cytometry
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for ErbB2/Her2 Antibody (191924) [DyLight 488]

  • CD340 antigen
  • CD340
  • c-erb B2/neu protein
  • EC 2.7.10
  • EGFR2
  • ErbB2
  • HER2
  • HER-2
  • HER2EC 2.7.10.1
  • herstatin
  • Metastatic lymph node gene 19 protein
  • MLN 19
  • MLN19
  • Neu Oncogene
  • NEUHER-2/neu
  • neuroblastoma/glioblastoma derived oncogene homolog
  • NGL
  • NGLTKR1
  • p185erbB2
  • Proto-oncogene c-ErbB-2
  • Proto-oncogene Neu
  • receptor tyrosine-protein kinase erbB-2
  • TKR1
  • Tyrosine kinase-type cell surface receptor HER2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)

Background

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for ErbB2/Her2 Antibody (FAB1129K). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in getting antibodies for HER that would work in flow cytometry. Could you recommend some choices?
    • A list of our ErbB2 antibodies validated for use in flow cytometry can be found here /productsearch/HER2#fq=common_name%3A%22ErbB2%2FHER2%22&fq=category%3A%22Primary%20Antibodies%22&fq=applications%3A%22Flow%20Cytometry%22

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Bioinformatics

Gene Symbol ERBB2