Clostridium Difficile Toxin A Antibody (actoxumab) Summary
| Description |
Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.
Also known as 'actoxumab'.
Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles. |
| Additional Information |
Recombinant Monoclonal Antibody |
| Immunogen |
Cdiff Toxin A |
| Isotype |
IgG1 |
| Clonality |
Monoclonal |
| Host |
Human |
| Purity |
Protein A purified |
| Endotoxin Note |
< 0.001EU/ug,determined by LAL method. |
| Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
| Dilutions |
- ELISA
- Flow Cytometry
- Functional
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. |
| Buffer |
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2) |
| Preservative |
No Preservative |
| Concentration |
LYOPH |
| Purity |
Protein A purified |
| Reconstitution Instructions |
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex. |
Alternate Names for Clostridium Difficile Toxin A Antibody (actoxumab)
Background
Clostridium difficile, or C. difficile, a gram positive anaerobic bacterium, is the major causative agent of colitis and diarrhoea that can occur following antibiotic intake. C. difficile infection is one of the most common hospital acquired infections. When C. difficile colonize the gut, they release two potent toxins, toxin A and toxin B, which bind to certain receptors in the lining of the colon and ultimately cause diarrhoea and inflammation of the large intestine.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Product General Protocols
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FAQs for Clostridium Difficile Toxin A Antibody (NBP3-28826). (Showing 1 - 1 of 1 FAQ).
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I am seeking monoclonal antibodies specific for the C Terminal binding regions of clostridum difficile toxins A and B (aa1852-2366)?
- I would recommend catalog # NB100-62473. Although it is a polyclonal, it is the only one that we know binds to the C-Terminal portion of the protein. The other antibodies we have against both targets are synthesized from the full length sequence. We do not routinely epitope map our antibodies so we cannot be certain where they are binding. This polyclonal is synthesized against a small 10 amino acid region of the protein so it should be highly specific to that location.
Secondary Antibodies
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Isotype Controls
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Additional Clostridium Difficile Toxin A Products
Blogs on Clostridium Difficile Toxin A
![Western Blot: Goat anti-Human IgG Fc Secondary Antibody [NB7446] - Image from verified customer review. Image using the HRP form of this antibody.](https://images.novusbio.com/images/Goat-anti-Human-IgG-Fc-Secondary-Antibody-Western-Blot-NB7446-img0001.jpg "Western Blot: Goat anti-Human IgG Fc Secondary Antibody [NB7446] - Image from verified customer review. Image using the HRP form of this antibody.")