Description
Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (
PGC-1alpha), PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha (theoretical molecular weight 91 kDa) belongs to a family of transcription coactivators which includes two other proteins;
PGC-1beta and
PGC-1-related coactivators. PGC1 alpha interacts with various transcription factors (e.g.,
FOXO1, PPAR-(
alpha,
delta and
gamma),
LXR and
FXR), promoting the transactivation of their specific target genes (1). As a transcription coactivator, PGC1 alpha is found in the nucleus where it interacts with transcriptional activators and chromatin modifiers such as
p300/CBP and
SRC-1 to induce targeted gene expression (1, 2).
Transcription factors which interact with PGC1 alpha are involved in several functions related to cellular energy homeostasis including
mitochondrial biogenesis,
glucose and fatty acid metabolism, and skeletal muscle remodeling. Upstream regulators of PGC1 alpha activity include proteins that play a central role as energy sensors including
SIRT1 and
AMPK which, through different mechanisms, induce PGC1 alpha activity (3).
PGC1 alpha is highly expressed in skeletal muscle, cardiac muscle, and brown adipose tissue, all tissues with high oxidative capacity (1, 2). PGC1 alpha is also induced by energy taxing physiological states, for example increased physical activity, reduced body temperature, and reduced food intake (3). Because of its role in pathways controlling cellular energy expenditure, PGC1 alpha dysfunction has been associated with pathophysiological conditions such as
type 2 diabetes and the metabolic syndrome (3).
References
1.Liang, H., & Ward, W. F. (2006). PGC-1alpha: A key regulator of energy metabolism. American Journal of Physiology - Advances in Physiology Education. https://doi.org/10.1152/advan.00052.2006
2.Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., ... Spiegelman, B. M. (2005). Transcriptional coactivator PGC-1alpha controls the energy state and contractile function of cardiac muscle. Cell Metabolism. https://doi.org/10.1016/j.cmet.2005.03.002
3.Canto, C., & Auwerx, J. (2009). PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Current Opinion in Lipidology. https://doi.org/10.1097/MOL.0b013e328328d0a4
Bioinformatics
| Uniprot |
Human
Human
|
| Product By Gene ID |
10891 |
| Alternate Names |
- LEM6
- Ligand effect modulator 6
- ligand effect modulator-6
- L-PGC-1alpha
- peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
- peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext
- peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a
- peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT
- peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
- PGC1
- PGC-1(alpha)
- PGC1A
- PGC-1-alpha
- PGC1APGC-1(alpha)
- PGC1peroxisome proliferative activated receptor, gamma, coactivator 1
- PGC-1v
- PPAR gamma coactivator variant form
- PPAR gamma coactivator-1
- PPARgamma coactivator 1alpha
- PPAR-gamma coactivator 1-alpha
- PPARGC1
- PPARGC-1-alpha
|
![Western Blot PGC1 alpha [p Ser571] Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/PGC1_alpha_AF6650_Western_Blot_10756.jpg)
