Perforin Products

Description

Perforin (PRF1) is a 70 kD cytolytic protein that is the major protein constituent of cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Specifically, perforin enters the target cell's plasma membrand and creates a intercellular pore to mediate targeted cell lysis. PRF1 antibodies are useful tools for lysis research on both CTLs and NK cells.

Bioinformatics

Uniprot	AAH63043.1 Human NM_005041 Human NP_001076585 Human NP_005032 Human NP_005032.2 Human P14222 Human Q5FVS5 Rat
Product By Gene ID	5551
Alternate Names	Cytolysin FLH2 HPLH2 HPLH2lymphocyte pore forming protein Lymphocyte pore-forming protein MGC65093 P1PFN1 perforin 1 (pore forming protein) perforin-1 PFPcytolysin

Research Areas for Perforin

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
Immunology

Related Perforin Blog Posts

Check out the latest blog posts on Perforin.

Perforin Antibodies Reveal Links to Apoptosis and Immune Response Perforin, also known as the pore-forming protein, pfp, is a 70 kD cytolytic protein expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It is one of the major effector molecules used by CTL and NK cel...    Read more.

Perforin Antibodies for Detecting Immune System Diseases  Perforin is a calcium-dependent pore forming cytolytic protein. Perforin is partially homologous to the terminal components of the membrane attack complex of complement and produces pores of up to 20nm in diameter on target membranes. Killer lymphocy...    Read more.

Perforin Antibodies Reveal Links to Apoptosis and Immune Response Perforin, also known as the pore-forming protein, pfp, is a 70 kD cytolytic protein expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It is one of the major effector molecules used by CTL and NK cel...    Read more.

Perforin a Protective Serial Killer Secretory granule-mediated cell death is one of the the key mechanisms for elimination of virus-infected and transformed target cells by cytotoxic lymphocytes. Formation of the immunological synapse between an effector and a target cell leads to exocy...    Read more.

You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers By Jamshed Arslan Pharm.D. Natural killer (NK) cells are lymphocytes of the innate immune system that were first discovered for their “natural” ability to kill cancer cells. To use NK cells as anti-cancer therapy, t...    Read more.

Read more Perforin related blogs.