Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IP, KD
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ELISA, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
OS9 is a lectin which functions in endoplasmic reticulum quality control and ER-associated degradation. This ER glycoprotein is found in the intralumenal level and highly expressed in tumor tissue. The OS9 gene is transcriptionally induced upon activation of the Ire1/Xbp1 ER-stress pathway.
Functionally, OS9 binds to HIF-1, a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. It may also bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. One such possible target includes TRPV4.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
10956 |
| Alternate Names |
- Amplified in osteosarcoma 9
- endoplasmic reticulum lectin 2
- ERLEC2
- erlectin 2
- OS-9
- osteosarcoma amplified 9, endoplasmic reticulum associated protein
- osteosarcoma amplified 9, endoplasmic reticulum lectin
- protein OS-9
|
Related OS9 Blog Posts
Check out the latest blog posts on OS9.
OS9: Taking proteins to the ER finish line
The OS9 protein is a lectin/glycoprotein that maintains endoplasmic reticulum (ER) quality control and ER-associated degradation (the so-called ERAD pathway) of newly synthesized proteins. It is essential for the recognition of terminally misfolded no... Read more.
|
Read more OS9 related blogs.
