Species: Hu, Mu
Applications: WB, ELISA, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Bv, Ch
Applications: WB, ELISA
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
p29 ING4 is a tumor suppressor protein similar to ING1 that may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/ NFKB3 target genes when complexed with RelA. p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. p29 ING4 shows a nuclear localization and interacts with EP300, TP53, RelA, inhibits cell growth, and induces apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Multiple alternatively spliced transcript variants have been observed. The accession number listed below is for variant (1) that encodes the longest isoform.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
51147 |
| Alternate Names |
- candidate tumor suppressor p33 ING1 homolog
- inhibitor of growth family, member 4
- inhibitor of growth protein 4
- MGC12557
- my036
- p29ING4brain my036 protein
|
