HSP90 Products

Description

Hsp90 has at least 2 isoforms, Hsp90a and Hsp90b which are encoded by separate genes. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steroid receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways.

Bioinformatics

Entrez	15516 Mouse 15519 Mouse 299331 Rat 301252 Rat 3320 Human
Uniprot	P07900 Human P07901 Mouse P08238 Human
Product By Gene ID	3320
Alternate Names	FLJ31884 Heat shock 86 kDa heat shock 90kD protein 1, alpha heat shock 90kD protein 1, alpha-like 4 heat shock 90kD protein, alpha-like 4 heat shock 90kDa protein 1, alpha heat shock protein 90kDa alpha (cytosolic), class A member 1 heat shock protein HSP 90-alpha Hsp89 Hsp90 HSP90AHSP86 HSP90N HSPC1HSP 86 HSPCAHSP89A HSPCAL1 HSPCAL4 HSPN LAP2 Renal carcinoma antigen NY-REN-38

Research Areas for HSP90

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Membrane Trafficking and Chaperones

Related HSP90 Blog Posts

Check out the latest blog posts on HSP90.

The Heat is On: Heat Shock Proteins and the Link to Cancer Novus Biologicals offers an extensive antibody catalog targeting heat shock proteins (HSPs). A large protein group covering a number of families, the HSPs are functionally related by their dramatic upregulation in response to stress. Stress triggers m...    Read more.

Heat Shock Proteins: An Overview Heat Shock Proteins (HSPs) are a ubiquitous group of molecular chaperone proteins that have evolved unique mechanisms, within their host cells, to facilitate survival in hostile environments such as heat, oxidative (hypoxia), pH and cold. Under permis...    Read more.

HSP Antibodies: Novel Therapies for MMP-induced Metastatic Breast Cancer The matrix metalloproteinases are zinc-dependent protease enzymes which interact with a range of ECM (extracellular matrix) proteins, and are activated by proteolytic cleavage. We at Novus Biologicals offer a wide range of top quality MMP reagents, in...    Read more.

Friends become Foes: Molecular Chaperons, Hsp70 and Hsp90, Cause Muscle Wasting in Cancers By Jamshed Arslan Pharm.D. Muscle atrophy is a common feature of many tumors. Cancer-induced muscle wasting, or cancer cachexia, results from pro-in?ammatory cytokines (TNFa and IL-6) and/or agonists of type IIB ac...    Read more.

Integrin beta 1 binding protein 2 ITGB1BP2 is a muscle-specific protein cloned by a rat created by Branccio's group in Italy that was found to interact with the cytoplasmic domain of integrin beta 11. It is expressed only in heart and skeletal muscle but is not essential for normal de...    Read more.

HSP90 - an essential eukaryotic protein with implications for drug development The heat-shock protein 90 (HSP90) family is a group of highly conserved molecular chaperones with important functions in protein folding and in signal transduction. The HSP90 protein structure is so well conserved that some HSP90 antibodies are rea...    Read more.

Read more HSP90 related blogs.