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Meckel-gruber Syndrome: Disease Bioinformatics

Research of Meckel-gruber Syndrome has been linked to Congenital Cerebral Hernia, Polycystic Kidney Diseases, Polydactyly, Dysplasia, Cystic Kidney Diseases. The study of Meckel-gruber Syndrome has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Meckel-gruber Syndrome include Localization, Pathogenesis, Transport, Intraflagellar Transport, Neural Tube Closure. These pathways complement our catalog of research reagents for the study of Meckel-gruber Syndrome including antibodies and ELISA kits against AFP, BBS2, NPHP1, PKHD1, PRKD1.

Top Research Reagents

We have 957 products for the study of Meckel-gruber Syndrome that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

PKHD1 Antibody (8G12A1)
NBP3-27118
Flow Cytometry: PKHD1 Antibody (8G12A1) [NBP3-27118] - Analysis of Hela cells using PKHD1 Rat mAb (green) and negative control (red).Immunohistochemistry: PKHD1 Antibody (8G12A1) [NBP3-27118] - Analysis of paraffin-embedded esophageal cancer tissues using PKHD1 Rat mAb with DAB staining.

Mouse Monoclonal
Species Human
Applications ELISA, Flow, ICC/IF

CEP290 Antibody
NB100-86991
Western Blot: CEP290 Antibody [NB100-86991] - Representative examples of immunoblot images of purified olfactory cilia. Three distinct cilia preparations each from LRBA-KO and WT mice (age, 4 weeks) were blotted in parallel (10 ug protein each), along with an OE and a brain sample (50 ug protein each), all shown at the same exposure. Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/s41598-017-08543-4) licensed under a CC-BY license.Immunocytochemistry/Immunofluorescence: CEP290 Antibody [NB100-86991] - NBF-fixed asynchronous HeLa cells. Antibody used at a dilution of 1:500.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IP

12 Publications
Inversin Antibody
NBP3-41327
Immunohistochemistry-Paraffin: Inversin Antibody [NBP3-41327] - DAB staining on IHC-P; Samples: Human Kidney Tissue; Primary Ab: 10ug/ml NBP3-41327; Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal AntibodyWestern Blot: Inversin Antibody [NBP3-41327] - Sample: Rat Kidney lysate; Primary Ab: 1ug/ml NBP3-41327; Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody

Rabbit Polyclonal
Species Human, Rat
Applications WB, IHC

BBS2 Antibody (9F10)
NBP3-42932
Western Blot: BBS2 Antibody (9F10) [NBP3-42932] - K-562 cells were subjected to SDS PAGE followed by western blot with (BBS2 Antibody) at dilution of 1:1000

Mouse Monoclonal
Species Human, Canine
Applications WB, ELISA, ICC/IF

RPGRIP1L Antibody
NBP1-84403
Immunohistochemistry-Paraffin: RPGRIP1L Antibody [NBP1-84403] - Staining of human bronchus shows strong cytoplasmic positivity in respiratory epithelial cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

2 Publications
Prosurfactant Protein C Antibody
NBP1-87201
Immunohistochemistry-Paraffin: Prosurfactant Protein C Antibody [NBP1-87201] - Analysis in human lung and kidney tissues using HPA010928 antibody. Corresponding SFTPC RNA-seq data are presented for the same tissues.Western Blot: Prosurfactant Protein C Antibody [NBP1-87201] - Analysis in human lung tissue.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
PKC mu Antibody
NBP1-87789
Immunocytochemistry/Immunofluorescence: PKC mu Antibody [NBP1-87789] - Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.Immunohistochemistry-Paraffin: PKC mu Antibody [NBP1-87789] - Staining of human parathyroid gland shows cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

1 Publication
MKS1 Antibody
NBP1-88692
Western Blot: MKS1 Antibody [NBP1-88692] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells), Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)Western Blot: MKS1 Antibody [NBP1-88692] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-345

Rabbit Polyclonal
Species Human, Rat
Applications WB, IHC, IHC-P

B9D2 Antibody
NBP1-91694
Western Blot: B9D2 Antibody [NBP1-91694] - Analysis in control (vector only transfected HEK293T lysate) and B9D2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: B9D2 Antibody [NBP1-91694] - Staining of human fallopian tube shows distinct positivity in ciliated cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

MKKS Antibody
NBP1-92123
Western Blot: MKKS Antibody [NBP1-92123] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG spImmunocytochemistry/Immunofluorescence: MKKS Antibody [NBP1-92123] - Immunofluorescent staining of human cell line U-2 OS shows localization to centrosome.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

CC2D2A Antibody
NBP1-93673
Immunohistochemistry-Paraffin: CC2D2A Antibody [NBP1-93673] - Staining of human placenta shows strong nuclear and cytoplasmic positivity in trophoblastic cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

1 Publication
AHI1 Antibody
NBP2-15309
Western Blot: AHI1 Antibody [NBP2-15309] - Sample (30 ug of whole cell lysate) A: IMR32 7.5% SDS PAGE; antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: AHI1 Antibody [NBP2-15309] - Analysis of methanol-fixed HeLa, using antibody at 1:500 dilution.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

alpha-Fetoprotein/AFP Antibody (189502) [Unconjugated]
MAB1368
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human/Mouse a-Fetoprotein/AFP Monoclonal Antibody (Catalog # MAB1368) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=a-Fetoprotein/AFP was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Mouse Anti-Human/Mouse a-Fetoprotein/AFP Monoclonal Antibody (Catalog # MAB1368) at 25 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=

Mouse Monoclonal
Species Human, Mouse
Applications WB, Simple Western, CyTOF-ready

     3 Reviews

90 Publications
Sonic Hedgehog/Shh [Unconjugated]
464-SH
Recombinant Mouse Sonic Hedgehog/Shh (C25Il), N-Terminus (Catalog # 464-SH) induces alkaline phosphatase production by the C3H10T1/2 mouse embryonic fibroblast cell line. The activity is more than 30-fold greater than the top competitor's Sonic Hedgehog.Recombinant Mouse Sonic Hedgehog/Shh (C25II), N-Terminus (Catalog # 464-SH) has a molecular weight (MW) of 20.7 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).


Species Mouse
Applications BA

69 Publications
Nesprin 2 Antibody
NBP2-42886
Western Blot: Nesprin 2 Antibody [NBP2-42886] - Various tissue extracts (50 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with Nesprin 2 antibody [C3], C-term diluted at 1:10000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.Immunohistochemistry-Paraffin: Nesprin 2 Antibody [NBP2-42886] - Rat brain. Nesprin 2 stained by Nesprin 2 antibody [C3], C-term diluted at 1:500.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

TRIM26 Antibody
NBP2-47594
Immunocytochemistry/Immunofluorescence: TRIM26 Antibody [NBP2-47594] - Staining human cell line A-431 shows positivity in cytoplasm and nucleus but excluded from the nucleoli.Immunohistochemistry-Paraffin: TRIM26 Antibody [NBP2-47594] - Staining of human tonsil shows strong cytoplasmic positivity in germinal center and non-germinal center cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

Meckelin Antibody
NBP1-06590
Western Blot: Meckelin Antibody [NBP1-06590] - Immunodetection of Meckelin (120kDa) in whole cell extracts of HEK293 cells.Immunohistochemistry: Meckelin Antibody [NBP1-06590] - Confocal maximum projection of acetylated alpha-tubulin (red) and meckelin (green) labelling in sections from unaffected and affected kidneys. In unaffected kidneys, meckelin was present within the cytoplasm of the epithelial cells and strongly localised to the base of the cilium. In contrast, meckelin was distributed along the length of the ciliary axonemes of affected cyst-lining cells. Meckelin distribution within the cytoplasm of cyst lining cells was similar to observations in unaffected epithelia. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28487520/) licensed under a CC-BY license.

Rabbit Polyclonal
Species Human, Rat
Applications WB, ICC/IF, IHC

2 Publications
B9D1 Antibody - BSA Free
NBP2-92821
Western Blot: B9D1 Antibody [NBP2-92821] - Analysis of extracts of various cell lines, using B9D1 at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.Immunocytochemistry/Immunofluorescence: B9D1 Antibody [NBP2-92821] - Immunofluorescence analysis of U2OS cells using B9D1 Rabbit pAb (NBP2-92821) at dilution of 1:100. Blue: DAPI for nuclear staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NPHP4 Antibody - Azide and BSA Free
NBP2-93637
Western Blot: NPHP4 Antibody [NBP2-93637] - Analysis of extracts of various cell lines, using NPHP4 .Exposure time: 30s.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF

Nephronophthisis Antibody - Azide and BSA Free
NBP2-94059
Western Blot: Nephronophthisis Antibody [NBP2-94059] - Analysis of extracts of Mouse pancreas, using NPHP1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit. Exposure time: 180s.Immunohistochemistry-Paraffin: Nephronophthisis Antibody [NBP2-94059] - Rat testis using NPHP1 Rabbit pAb at dilution of 1:50 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF


Related Genes

Meckel-gruber Syndrome has been researched against:

Related Pathways

Meckel-gruber Syndrome has been linked to:

Related Diseases

Meckel-gruber Syndrome has been studied in relation to diseases such as:

Related PTMs

Meckel-gruber Syndrome has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Meckel-gruber Syndrome is also known as Dysencephalia Splachnocystica, Dysencephalia Splanchnocystica, Gruber Syndrome, Meckel Gruber Syndrome, Meckel Syndrome.