Species: Hu, Mu, Rt, Bv, Ca
Applications: ELISA, ICC/IF, IHC
Host: Goat Polyclonal
Species: Mu, Rt
Applications: WB, ELISA, KO
Host: Goat Polyclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28 and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
23318 |
| Alternate Names |
- DKFZp779C1943
- EC 2.7.7.52
- KIAA0191FLJ42878
- PAP associated domain containing 3
- PAPD3
- terminal uridylyltransferase 4
- TUT4
- TUTase 4
- Zinc finger CCHC domain-containing protein 11
- zinc finger, CCHC domain containing 11
|
Research Areas for ZCCHC11/TUT4
Find related products by research area and learn more about each of the different research areas below.
Cell Cycle and Replication
