VAV2 Products

Description

The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). Vav and Vav2 are members of the dbl family of guanine nucleotide exchange factors (GEF) for the rho/rac family of GTP binding proteins. Vav is expressed primarily in hematopoietic cells, while vav2 has a wider tissue distribution (2). Vav2 serves as a guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Unlike Vav1, whose expression is restricted to cells of hematopoietic origin, Vav2 is broadly expressed. Recently, Vav2 has been identified as a substrate for the epidermal growth factor (EGF) receptor. EGF receptor phosphorylates Vav2 on all three possible phosphorylation sites, Tyr-142, Tyr-159, and Tyr-172. results suggest that EGF regulates Vav2 activity basically through phosphatidylinositol 3-kinase activation, whereas tyrosine phosphorylation of Vav2 may rather be necessary for mediating protein-protein interactions (3)

Bioinformatics

Entrez	22325 Mouse 296603 Rat 7410 Human
Uniprot	NM_003371 Human NP_003362 Human NP_003362. Human P52735 Human
Product By Gene ID	7410
Alternate Names	guanine nucleotide exchange factor VAV2 oncogene VAV2 Protein vav-2 vav 2 guanine nucleotide exchange factor vav 2 oncogene VAV-2

Research Areas for VAV2

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction