Vav-1 Products

Description

The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels (2). As a signaling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein (3). Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response (2).

Bioinformatics

Entrez	22324 Mouse 25156 Rat 7409 Human
Uniprot	AAH13361 Human NM_005428 Human P15498 Human
Product By Gene ID	7409
Alternate Names	oncogene vav proto-oncogene vav vav 1 guanine nucleotide exchange factor vav proto-oncogene VAVvav 1 oncogene

Research Areas for Vav-1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction