Vanin-1/VNN1 Products

Description

VNN1 encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq]

Bioinformatics

Entrez	8876 Human
Uniprot	NM_004666 Human NP_004657 Human
Product By Gene ID	8876
Alternate Names	EC 3.5.1 EC 3.5.1.92 HDLCQ8 MGC116930 MGC116931 MGC116932 pantetheinase Pantetheine hydrolase Tiff66MGC116933 vanin 1 vanin-1 Vanin-1 vannin 1 Vascular non-inflammatory molecule 1