UGT1A10 Products

Description

UGT1A10 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq]

Bioinformatics

Entrez	54575 Human
Uniprot	AAH20971 Human NP_061948 Human
Product By Gene ID	54575
Alternate Names	GNT1 UDP glucuronosyltransferase 1 family, polypeptide A10 UDP glycosyltransferase 1 family, polypeptide A10 UDP-glucuronosyltransferase 1-10 UDP-glucuronosyltransferase 1A10 UDP-glucuronosyltransferase 1-J UDPGT 1-10 UDPGT UGT1 UGT1*10 UGT1.10 UGT1-10 UGT-1J UGT1JEC 2.4.1.17

Research Areas for UGT1A10

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Cancer